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KMID : 0387420050160010043
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Korean Society of Oriental Neuropsychiatry
2005 Volume.16 No. 1 p.43 ~ p.66
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The Effects on Kunneotang of Patients with Early Dementia of Alzheimer Type -12 Months Clinical Study-
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Eom Hoy-Jin
Kim Jong-Woo
Park Eun-Hye
Kim Hyun-Taek
Hwang Wei-Wan
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Abstract
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Objects:This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT.
Method: Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again.
Results: 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference.
Conclusion:The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.
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KEYWORD
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Kunneotang, early DAT, auditory ERP, MMSE-K, K-DRS, clinical trial
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